Angelina Jolie underwent a preventive double mastectomy after doctors estimated she had an 87% chance of developing breast cancer. How was that figure calculated and how does it differ from other women's risk of getting the disease?

安吉丽娜·朱莉在医生估计她有87%的几率患乳腺癌的风险后接受了预防性双乳切除手术。这个几率是怎么计算出的并且它如何不同于其他女性的患该疾病的风险?

The BRCA1 is present in everyone but only mutates in one in 1,000 people. Anyone with the mutation has a 50-80% chance of developing breast cancer.

存在于每个人的BRCA1只有千分之一的可能发生变异，但任何人一旦发生突变就会有50 - 80%的几率发展为乳腺癌。

But Jolie's risk figure was calculated to be even higher because of other factors, including family history.

但是朱莉的风险计算相比于别人可能会更高,因为她有包括家庭病史这样的其他因素。